منابع مشابه
A disheartening story: Aprotinin in cardiac surgery
Results: In propensity-adjusted, multivariable logistic regression (C-index, 0.72), use of aprotinin was associated with a doubling in the risk of renal failure requiring dialysis among patients undergoing complex coronary-artery surgery (odds ratio, 2.59; 95 percent confidence interval, 1.36 to 4.95) or primary surgery (odds ratio, 2.34; 95 percent confidence interval, 1.27 to 4.31). Similarly...
متن کاملAprotinin and lysine analogues in high-risk cardiac surgery.
BACKGROUND Antifibrinolytic agents are commonly used during cardiac surgery to minimize bleeding and to reduce exposure to blood products. We sought to determine whether aprotinin was superior to either tranexamic acid or aminocaproic acid in decreasing massive postoperative bleeding and other clinically important consequences. METHODS In this multicenter, blinded trial, we randomly assigned ...
متن کاملAnesthesia Issues in Cardiac Surgery
The principle of anaesthesia for open-heart surgery is based on simplicity, safty and lightplane of anaesthesia. As a result of the special pathophysiology, grave general status, complications threatening these patients during and after the operation and the abundance of medicines available nowadays, it is very important for the anaesthetist to be acquainted with the pathophysiological and ph...
متن کاملUse of aprotinin in knee replacement surgery.
We have studied the effect of aprotinin on blood loss and subsequent blood transfusion in 17 patients undergoing knee replacement surgery. Patients receiving aprotinin (total dose 2,000,000 kallikrein inhibiting units) received fewer units of blood than control patients (P < 0.05), although there was no significant difference in blood loss between the two groups. The study was stopped when one ...
متن کاملUse of aprotinin in cardiac surgery: effectiveness and safety in a population-based study.
OBJECTIVE The effectiveness and safety of aprotinin use in cardiac surgery have been questioned. More data reflecting everyday clinical practice from large-scale, unselected populations are needed. We compared the effectiveness and safety of aprotinin in cardiac surgery with those of tranexamic acid in a follow-up study using the population-based Danish health-care databases. METHODS We ident...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 1993
ISSN: 0022-5223
DOI: 10.1016/s0022-5223(19)33756-0